Objective: Ocuserts are sterile, solid, or semisolid dosage forms prepared to attain increased contact time between the drug and the conjunctival tissue to keep up a constant release of drug when placed in the lower cul-de-sac or conjunctival sac of the eye. The article here under gives a detailed idea about the classification, mechanism of action, formulation, pros and cons evaluation and future trends of ocular inserts. Ocular inserts are an alternative approach to overcome the problems associated with conventional ocular dosage forms like solutions, suspensions, ointments, etc. These are sterile preparations, with a thin, multilayered, drug-impregnated, solid or semisolid consistency devices placed into cul-de-sac or conjunctiva sac of the eye. Ocular insert is an example of such delivery system. At present, various novel and controlled drug delivery systems are being d eveloped in order to attain better ocular bioavailability, sustained action of ocular drugs as well as good patient compliance. Hence novel drug delivery strategies and formulations are to be developed and explored which will overcome the ocula r constraints and provide better patient compliance. The article discusses soluble ocular drug insert (SODI), Ocusert, Collagen Shields, Ocufit, Minidisc and new ophthalmic delivery system (NODS) with special attention to biological/clinical performances, and potential for future applications and developments.Īmong the ocular dosage forms, the physiological and anatomical constraints put forth by the eye is a significant challenge to the pharmaceutical scientists and researchers to target drugs to the posterior segment of the eye, prolong their contact time with the ocular surface and sustained release. In the present update, the authors discuss the basic concept of ocular inserts as drug delivery system and examine the few inserts, which are available in the market or are being developed by pharmaceutical companies for drug delivery. Utilization of the principles of controlled release as embodied by ocular inserts offers an attractive approach to the problem of prolonging pre-corneal drug residence times. In the recent years, there has been explosion of interest in the polymer based delivery devices. However, the design of ocular system is undergoing gradual transition from an empirical to rational basis. The existing ocular drug delivery systems are fairly primitive and inefficient. Ocular diseases require localized administration of drugs to the tissues around the ocular cavity.
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